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Histol Histopathol. 2007 May;22(5):581-6.

Macrophages in rheumatoid arthritis.

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  • 1University of Foggia Medical School, Foggia, Italy.

Abstract

In rheumatoid arthritis (RA) tissue macrophages release growth factors, matrix metalloproteinases, cytokines, and chemokines. While in normal joints there is a balance between proinflammatory and anti-inflammatory cytokines, an imbalance between these inducers and inhibitors of inflammation occurs in RA, where macrophages are responsible for inducing inflammation, matrix destruction and angiogenesis.

PMID:
17330813
[PubMed - indexed for MEDLINE]
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