Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Clin Trials. 2007;4(1):32-41.

Innovative approaches to cohort retention in a community-based HIV/STI prevention trial for socially marginalized Peruvian young adults.

Author information

  • 1Universidad Peruana Cayetano Heredia, Lima, Peru. 06688@upch.edu.pe

Abstract

BACKGROUND:

The conduct of longitudinal clinical trials must involve effective strategies to retain study participants in order to ensure internal validity, adequate statistical power and generalizability of results.

PURPOSE:

In a large trial in Peru, we implemented various retention strategies to maintain high participation rates over time.

METHODS:

Novel participant retention strategies were used to follow highly marginalized populations for two years because traditional locator information, such as telephone numbers and official identification (eg, passport, driver's license, the local equivalent of a social security number) were often unreliable or unavailable. These strategies included detailed preliminary ethnographic research to identify the behaviours of key target groups, approaches to develop strong informal bonds between project staff and participants outside of study settings, and methods to enhance positive participant attitudes towards the study.

RESULTS:

The overall study retention rate after two years was 84%, even though only 26% of the study populations supplied complete locator information (telephone, address and the names of two friends).

LIMITATIONS:

The retention strategies used were labour intensive and iterative, which could prove difficult to replicate.

CONCLUSIONS:

The two-year retention rate in this study was sufficient to maintain required sample sizes. The methods used to maintain contact with the populations were labour intensive, low tech and adequate for these populations and could be used to retain study participants in other marginalized, urban, low-income areas.

PMID:
17327244
[PubMed - indexed for MEDLINE]
PMCID:
PMC2853960
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk