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Org Lett. 2007 Mar 29;9(7):1203-6. Epub 2007 Feb 28.

A rapid and simple cleanup procedure for metathesis reactions.

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  • 1Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.


[structure: see text]. A new method for easy removal of ruthenium from metathesis reactions by using a polar isocyanide is reported. This protocol removed most ruthenium byproducts from a variety of synthetically useful metatheses. Moreover, the isocyanide-promoted carbene insertion results in rapid destruction of carbene reactivity, demonstrated in the commonly used first- and second-generation Grubbs' carbenes.

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