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Chem Soc Rev. 2007 Mar;36(3):471-83. Epub 2006 Oct 17.

Synthetic metallomolecules as agents for the control of DNA structure.

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  • 1Molecular Organisation and Assembly in Cells Doctoral Training Centre, University of Warwick, Coventry, CV4 7AL, UK.


This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes, metallohelicates and platinum complexes such as cis-platin are discussed alongside the techniques of NMR, X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics. The review will be of interest to people interested in both DNA structure and roles of metallomolecules in biological systems.

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