Nat Rev Microbiol. 2007 Apr;5(4):253-63. Epub 2007 Feb 26.

Host factors exploited by retroviruses.

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Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute HHSC 1310c, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, New York 10032, USA. goff@cancercenter.columbia.edu

Abstract

Retroviruses make a long and complex journey from outside the cell to the nucleus in the early stages of infection, and then an equally long journey back out again in the late stages of infection. Ongoing efforts are identifying an enormous array of cellular proteins that are used by the viruses in the course of their travels. These host factors are potential new targets for therapeutic intervention.

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