J Gen Virol. 2007 Mar;88(Pt 3):951-5.

Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection.

Gocník M, Fislová T, Sládková T, Mucha V, Kostolanský F, Varecková E.

Source

Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic.

Abstract

Four monoclonal antibodies (mAbs) recognizing distinct antigenic sites on the HA2 glycopolypeptide of influenza virus A/Dunedin/4/73 (H3N2) have been tested for in vivo protection. When applied intravenously before infection, three of them increased the survival of BALB/c mice infected with 1 LD50 homologous virus. The protection resulted simultaneously in 2 days earlier clearance of virus from the lungs. These three antibodies inhibited the fusion activity of virus in previous in vitro experiments. One of them, specific to N-terminal aa 1-38 of the HA2 glycopolypeptide, was also tested for protection against the heterologous virus A/Mississippi/1/85 (H3N2). Protection similar to that against the homologous virus was observed. The fourth mAb, without fusion-inhibition activity, did not protect mice. It is concluded that antibodies specific to the antigenically conserved HA2 glycopolypeptide that exhibit fusion-inhibition activity can contribute to the protection of infected mice and mediate more effective recovery from infection.

PMID:: 17325369; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Flu - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Heterosubtypic protective immunity against influenza A virus induced by fusion peptide of the hemagglutinin in comparison to ectodomain of M2 protein. [Acta Virol. 2011]
Heterosubtypic protective immunity against influenza A virus induced by fusion peptide of the hemagglutinin in comparison to ectodomain of M2 protein.
Staneková Z, Király J, Stropkovská A, Mikušková T, Mucha V, Kostolanský F, Varečková E. Acta Virol. 2011; 55(1):61-7.
Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection. [J Gen Virol. 2008]
Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection.
Gocník M, Fislová T, Mucha V, Sládková T, Russ G, Kostolansky F, Varecková E. J Gen Virol. 2008 Apr; 89(Pt 4):958-67.
Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. [J Virol. 2009]
Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection.
Prabhu N, Prabakaran M, Ho HT, Velumani S, Qiang J, Goutama M, Kwang J. J Virol. 2009 Mar; 83(6):2553-62. Epub 2008 Dec 24.
Review [Tetravaccine--new fundamental approach to prevention of influenza pandemic]. [Zh Mikrobiol Epidemiol Immunob...]
Review [Tetravaccine--new fundamental approach to prevention of influenza pandemic].
Onishchenko GG, Zverev VV, Katlinskiĭ AV, Semchenko AV, Korovkin SA, Mel'nikov SIa, Mironov AN. Zh Mikrobiol Epidemiol Immunobiol. 2007 Jul-Aug; (4):15-9.
Review The role of the antibody response in influenza virus infection. [Curr Top Microbiol Immunol. 2001]
Review The role of the antibody response in influenza virus infection.
Gerhard W. Curr Top Microbiol Immunol. 2001; 260:171-90.

See reviews... See all...

Cited by 6 PubMed Central articles

Targets for the induction of protective immunity against influenza a viruses. [Viruses. 2010]
Targets for the induction of protective immunity against influenza a viruses.
Bodewes R, Osterhaus AD, Rimmelzwaan GF. Viruses. 2010 Jan; 2(1):166-88. Epub 2010 Jan 14.
Serological response to the 2009 pandemic influenza A (H1N1) virus for disease diagnosis and estimating the infection rate in Thai population. [PLoS One. 2011]
Serological response to the 2009 pandemic influenza A (H1N1) virus for disease diagnosis and estimating the infection rate in Thai population.
Lerdsamran H, Pittayawonganon C, Pooruk P, Mungaomklang A, Iamsirithaworn S, Thongcharoen P, Kositanont U, Auewarakul P, Chokephaibulkit K, Oota S, et al. PLoS One. 2011 Jan 25; 6(1):e16164. Epub 2011 Jan 25.
Review Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development. [Virol J. 2010]
Review Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development.
Staneková Z, Varečková E. Virol J. 2010 Nov 30; 7:351. Epub 2010 Nov 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemaggluti...
Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection.
J Gen Virol. 2007 Mar ;88(Pt 3):951-5.

PubMed
Narrative criticism: a systematic approach to the analysis of story.
Narrative criticism: a systematic approach to the analysis of story.
J Holist Nurs. 2007 Mar ;25(1):58-65; quiz 66-7.

PubMed
Risk of tuberculosis from exposure to tobacco smoke: a systematic review and met...
Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis.
Arch Intern Med. 2007 Feb 26 ;167(4):335-42.

PubMed
Incremental value of strain rate imaging to wall motion analysis for prediction ...
Incremental value of strain rate imaging to wall motion analysis for prediction of outcome in patients undergoing dobutamine stress echocardiography.
Circulation. 2007 Mar 13 ;115(10):1252-9. Epub 2007 Feb 26 .

PubMed
Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexua...
Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and sexual-stage parasites in falciparum malaria in children.
Antimicrob Agents Chemother. 2007 May ;51(5):1694-9. Epub 2007 Feb 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information