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Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):123-37.

Brain micro-ecologies: neural stem cell niches in the adult mammalian brain.

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  • 1Center for Neurobiology and Behavior, Columbia University, 630 West 168th Street, New York City, NY 10032, USA.

Abstract

Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are neural stem cells, capable of self-renewing and generating neurons and glia. Cues within the niche, from cell-cell interactions to diffusible factors, are spatially and temporally coordinated to regulate proliferation and neurogenesis, ultimately affecting stem cell fate choices. Here, we review the components of adult neural stem cell niches and how they act to regulate neurogenesis in these regions.

PMID:
17322003
[PubMed - indexed for MEDLINE]
PMCID:
PMC2605490
Free PMC Article
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