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1: Ann Intern Med. 1975 Nov;83(5):654-6.Links

Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion.

Cherrill DA, Stote RM, Birge JR, Singer I.

We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.

PMID: 173218 [PubMed - indexed for MEDLINE]

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  • Demeclocycline (Declomycin® )

    Demeclocycline is used to treat bacterial infections including pneumonia and other respiratory tract infections; acne; and infections of skin, genital, and urinary systems. Demeclocycline is in a class of medications cal...

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