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PLoS Pathog. 2007 Feb;3(2):e17.

A new inhibitor of apoptosis from vaccinia virus and eukaryotes.

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  • 1Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom. c.gubser@imperial.ac.uk

Abstract

A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein). Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Conversely, knockout of h-GAAP by siRNA induced cell death by apoptosis. v-GAAP and h-GAAP display overlapping functions as shown by the ability of v-GAAP to complement for the loss of h-GAAP. Lastly, deletion of the v-GAAP gene from vaccinia virus did not affect virus replication in cell culture, but affected virus virulence in a murine infection model. This study identifies a new regulator of cell death that is highly conserved in evolution from plants to insects, amphibians, mammals, and poxviruses.

PMID:
17319741
[PubMed - indexed for MEDLINE]
PMCID:
PMC1803007
Free PMC Article
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