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Mol Aspects Med. 2007 Oct-Dec;28(5-6):668-91. Epub 2007 Jan 11.

Anti-inflammatory properties of alpha- and gamma-tocopherol.

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  • 1Institute for Infectious Diseases, University of Berne, Friedbühlstrasse 51, CH-3010 Berne, Switzerland.

Abstract

Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin E, alpha-tocopherol (alphaT) and gamma-tocopherol (gammaT), and discuss the potential molecular mechanisms involved in these effects. While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gammaT-enriched) tocopherols seems to be more potent than supplementation with alphaT alone. This may explain the mostly negative outcomes of the recent large-scale interventional chronic disease prevention trials with alphaT only and thus warrants further investigation.

PMID:
17316780
[PubMed - indexed for MEDLINE]
PMCID:
PMC2613571
Free PMC Article

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