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Kidney Int. 2007 Mar;71(5):374-6.

Aldosterone antagonists: silver bullet or just sodium excretion and potassium retention?

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  • 1University Hospital of Hamburg, Department of Medicine, Division of Nephrology, Hamburg, Germany.


ACE inhibitors or AT(1) antagonists are powerful therapeutic strategies to slow the progression of renal disease. However, they provide only imperfect protection since they cannot always prevent end-stage renal failure. Innovative approaches are needed to keep patients with chronic kidney disease off dialysis. Blockade of the aldosterone pathway may prove to be such a beneficial therapeutic concept.

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