AIDS. 2007 Mar 12;21(5):645-7.

HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.

Jung S, Eichenmüller M, Donhauser N, Neipel F, Engel AM, Hess G, Fleckenstein B, Reil H.

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Institute of Clinical and Molecular Virology, University Hospital of the Friedrich-Alexander-Universität, Erlangen-Nuremberg, Germany.

Abstract

Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.

PMID:: 17314528; [PubMed - indexed for MEDLINE]

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HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.
HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.
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