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    Cell Cycle. 2007 Jan 15;6(2):115-6. Epub 2007 Jan 17.

    Caveolin-1 and liver regeneration: role in proliferation and lipogenesis.

    Frank PG, Lisanti MP.

    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Philippe.Frank@jefferson.edu

    Caveolin-1 is an essential component of caveolae, which form 50-100 nm cell surface plasma membrane invaginations. Caveolin-1 has been previously implicated in the regulation of cellular proliferation and lipogenesis. Current data now suggest that caveolin-1 plays an essential role in the regulation of liver regeneration and that it is implicated in the regulation of triglyceride accumulation, which is an essential process that plays a critical role in the regulation of liver regeneration. These findings are consistent with the importance of a lipogenesis program in the regulation of liver regeneration.

    PMID: 17314510 [PubMed - indexed for MEDLINE]

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