Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Mutat Res. 2007 May 1;618(1-2):116-29. Epub 2007 Jan 21.

Transcription through chromatin by RNA polymerase II: histone displacement and exchange.

Author information

  • 1Department of Pharmacology, UMDNJ, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.


The process of transcript elongation by RNA polymerase II (Pol II) involves transcription-dependent exchange and displacement of all core histones and is tightly controlled by numerous protein complexes modifying chromatin structure. These processes can contribute to regulation of transcription initiation and elongation, as well as the chromatin state. Recent data suggest that the histone octamer is displaced from DNA at a high rate of transcription, but can survive less frequent transcription that is accompanied only by partial loss of H2A/H2B histones. Here we propose that critical density of Pol II molecules could be required for displacement of the histone octamer and discuss mechanisms that are most likely involved in the processes of histone exchange.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk