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Nature. 1992 Jan 16;355(6357):219-24.

Chromatin as an essential part of the transcriptional mechanism.

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  • 1Laboratory of Molecular Biology, National Institutes of Health, Bethesda, Maryland 20892.


The increasingly detailed biochemical definition of the protein complexes that regulate gene transcription has led to the re-emergence of questions about the role of histones. Much recent evidence suggests that transcriptional activation requires that transcription factors successfully compete with histones for binding to promoters, and that there may be more than one mechanism by which this is achieved.

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