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J Clin Endocrinol Metab. 2007 May;92(5):1673-7. Epub 2007 Feb 20.

Breast milk iodine and perchlorate concentrations in lactating Boston-area women.

Author information

  • 1Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center and Boston University School of Medicine, 88 East Newton Street, Evans 201, Boston, MA 02118, USA. elizabeth.pearce@bmc.org

Abstract

CONTEXT:

Breastfed infants rely on adequate maternal dietary iodine intake.

OBJECTIVE:

Our objective was to measure breast milk iodine and perchlorate, an inhibitor of iodide transport into the thyroid and potentially into breast milk, in Boston-area women.

PARTICIPANTS:

The study included 57 lactating healthy volunteers in the Boston area.

MEASUREMENTS:

Breast milk iodine and perchlorate concentrations and urine iodine, perchlorate, and cotinine concentrations were measured. For comparison, iodine and perchlorate levels in infant formulae were also measured.

RESULTS:

Median breast milk iodine content in 57 samples was 155 microg/liter (range, 2.7-1968 microg/liter). Median urine iodine was 114 microg/liter (range, 25-920 microg/liter). Perchlorate was detectable in all 49 breast milk samples (range, 1.3-411 microg/liter), all 56 urine samples (range, 0.37-127 microg/liter), and all 17 infant formula samples (range, 0.22-4.1 microg/liter) measured. Breast milk iodine content was significantly correlated with urinary iodine per gram creatinine and urinary cotinine but was not significantly correlated with breast milk or urinary perchlorate.

CONCLUSIONS:

Perchlorate exposure was not significantly correlated with breast milk iodine concentrations. Perchlorate was detectable in infant formula but at lower levels than in breast milk. Forty-seven percent of women sampled may have been providing breast milk with insufficient iodine to meet infants' requirements.

PMID:
17311853
[PubMed - indexed for MEDLINE]
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