Source
Research Centre on Aging, Sherbrooke, Québec, Canada.
Abstract
OBJECTIVE:
The aim of this study was to verify if six months of isoflavone supplementation could increase fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height(2)) in obese-sarcopenic postmenopausal women.
DESIGN:
Double-blind randomized study.
SUBJECT:
Eighteen sarcopenic-obese women completed the study (12 on isoflavones and six on placebo). Body composition was measured by dual-energy X-ray absorptiometry. Subjects ingested 70 mg of isoflavones per day (44 mg of diadzein, 16 mg glycitein and 10 mg genestein) or a placebo for 24 weeks.
RESULTS:
The isoflavone group increased significantly appendicular (P=0.034), leg (P=0.016) FFM and MMI (P=0.037), but not the placebo group.
CONCLUSION:
Six months of isoflavone supplementation increased FFM and MMI in obese-sarcopenic postmenopausal women.