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Nat Rev Neurosci. 2007 Mar;8(3):182-93.

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.

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  • 1The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, UK.


In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.

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