The first topologically controlled synthesis of doubly bridged beta-cyclodextrin dimers

De-Qi Yuan; Kazutaka Koga; Isao Kouno; Toshihiro Fujioka; Makoto Fukudome; Kahee Fujita

doi:10.1039/b613959k

The first topologically controlled synthesis of doubly bridged beta-cyclodextrin dimers

Chem Commun (Camb). 2007 Feb 28:(8):828-30. doi: 10.1039/b613959k. Epub 2006 Nov 21.

Authors

De-Qi Yuan¹, Kazutaka Koga, Isao Kouno, Toshihiro Fujioka, Makoto Fukudome, Kahee Fujita

Affiliation

¹ Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki, 852-8521, Japan. deqiyuan@nagasaki-u.ac.jp

PMID: 17308645
DOI: 10.1039/b613959k

Abstract

Reaction 6(A),6(B)-di(O-tosyl)-beta-cyclodextrin with Na(2)S in DMF gave the cis-dimer of beta-cyclodextrin in 21% isolated yield while the trans-dimer was not detected.

MeSH terms

Crystallography, X-Ray
Indicators and Reagents
Isomerism
Magnetic Resonance Spectroscopy
Models, Molecular
Spectrometry, Mass, Fast Atom Bombardment
Sulfides
beta-Cyclodextrins / chemical synthesis*

Substances

Indicators and Reagents
Sulfides
beta-Cyclodextrins
sodium sulfide