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1: Behav Brain Res. 2007 Apr 16;179(1):1-18. Epub 2007 Jan 31.Click here to read Links

What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression.

Kalueff AV, Wheaton M, Murphy DL.

Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892-1264, USA. kalueff@inbox.ru.

Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.

PMID: 17306892 [PubMed - indexed for MEDLINE]