Nat Rev Microbiol. 2007 Mar;5(3):187-96.

The road to chromatin - nuclear entry of retroviruses.

Source

Laboratory for Host Factors, Center for Emerging Virus Research, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Abstract

Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA copy of their genome after entry into the host cell. Integration of this DNA into the host cell's genome is an essential step in the viral replication cycle. The viral DNA is synthesized in the cytoplasm and is associated with viral and cellular proteins in a large nucleoprotein complex. Before integration into the host genome can occur, this complex must be transported to the nucleus and must cross the nuclear envelope. This Review summarizes our current knowledge of how this journey is accomplished.

PMID:: 17304248; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells. [J Virol. 2003]
Human immunodeficiency virus type 1 DNA nuclear import and integration are mitosis independent in cycling cells.
Katz RA, Greger JG, Boimel P, Skalka AM. J Virol. 2003 Dec; 77(24):13412-7.
Review A hard way to the nucleus. [Mol Med. 2004]
Review A hard way to the nucleus.
Bukrinsky M. Mol Med. 2004 Jan-Jun; 10(1-6):1-5.
Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. [Proc Natl Acad Sci U S A. 1992]
Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.
Bukrinsky MI, Sharova N, Dempsey MP, Stanwick TL, Bukrinskaya AG, Haggerty S, Stevenson M. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6580-4.
Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. [Retrovirology. 2008]
Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors.
Studamire B, Goff SP. Retrovirology. 2008 Jun 13; 5:48. Epub 2008 Jun 13.
Review Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV? [Curr Drug Targets. 2003]
Review Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?
Piller SC, Caly L, Jans DA. Curr Drug Targets. 2003 Jul; 4(5):409-29.

See reviews... See all...

Cited by 46 PubMed Central articles

Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming. [PLoS One. 2012]
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
Chen M, Huang J, Yang X, Liu B, Zhang W, Huang L, Deng F, Ma J, Bai Y, Lu R, et al. PLoS One. 2012; 7(4):e28203. Epub 2012 Apr 18.
C. elegans germ cells show temperature and age-dependent expression of Cer1, a Gypsy/Ty3-related retrotransposon. [PLoS Pathog. 2012]
C. elegans germ cells show temperature and age-dependent expression of Cer1, a Gypsy/Ty3-related retrotransposon.
Dennis S, Sheth U, Feldman JL, English KA, Priess JR. PLoS Pathog. 2012 Mar; 8(3):e1002591. Epub 2012 Mar 29.
Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import. [Retrovirology. 2011]
Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import.
Cribier A, Ségéral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S. Retrovirology. 2011 Dec 16; 8:104. Epub 2011 Dec 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The road to chromatin - nuclear entry of retroviruses.
The road to chromatin - nuclear entry of retroviruses.
Nat Rev Microbiol. 2007 Mar ;5(3):187-96.

PubMed
Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent ...
Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.
EMBO J. 2007 Mar 7 ;26(5):1352-62. Epub 2007 Feb 15 .

PubMed
[Long-term follow-up of multifocal motor neuropathy with conduction block under ...
[Long-term follow-up of multifocal motor neuropathy with conduction block under intravenous immunoglobulin].
Rev Neurol (Paris). 2007 Jan ;163(1):82-8.

PubMed
Neonatal withdrawal syndrome after chronic maternal drinking of mate.
Neonatal withdrawal syndrome after chronic maternal drinking of mate.
Ther Drug Monit. 2007 Feb ;29(1):127-9.

PubMed
Does facet joint inflammation induce radiculopathy?: an investigation using a ra...
Does facet joint inflammation induce radiculopathy?: an investigation using a rat model of lumbar facet joint inflammation.
Spine (Phila Pa 1976). 2007 Feb 15 ;32(4):406-12.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: