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Blood. 2007 Jun 1;109(11):4786-92. Epub 2007 Feb 15.

Moderation of the platelet releasate response by aspirin.

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  • 1Department of Cell Biology, Scripps Research Institute, La Jolla, CA, USA.


Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.

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