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Mutat Res. 2007 May 1;618(1-2):52-64. Epub 2007 Jan 21.

Chromatin disassembly and reassembly during DNA repair.

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  • 1Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, CO 80045, USA.

Abstract

Current research is demonstrating that the packaging of the eukaryotic genome together with histone proteins into chromatin is playing a fundamental role in DNA repair and the maintenance of genomic integrity. As is well established to be the case for transcription, the chromatin structure dynamically changes during DNA repair. Recent studies indicate that the complete removal of histones from DNA and their subsequent reassembly onto DNA accompanies DNA repair. This review will present evidence indicating that chromatin disassembly and reassembly occur during DNA repair and that these are critical processes for cell survival after DNA repair. Concomitantly, candidate proteins utilized for these processes will be highlighted.

PMID:
17303193
[PubMed - indexed for MEDLINE]
PMCID:
PMC2593076
Free PMC Article

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