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    Math Biosci. 2007 Aug;208(2):644-57. Epub 2007 Jan 12.

    Identifiability of the joint distribution of age and tumor size at detection in the presence of screening.

    Hanin L, Yakovlev A.

    Department of Mathematics, Idaho State University, Pocatello, ID 83209-8085, USA. hanin@isu.edu

    In recent years, a stochastic model of cancer development and detection allowing for arbitrary screening schedules has been developed and applied to analysis of screening trials and population-based cancer incidence and mortality data. The model is entirely mechanistic, builds on a minimal set of biologically plausible assumptions, and yields the joint distribution of tumor size and age of a patient at the time of diagnosis. Whether or not parameters of the model can be estimated from data generated by cohort studies depends on model identifiability. The present paper provides a proof of this important property of the model.

    PMID: 17303192 [PubMed - indexed for MEDLINE]

    PMCID: 2041843

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