Ugeskr Laeger. 2007 Feb 5;169(6):497-9.

[Intervention with clarithromycin in patients with stable coronary heart disease--the CLARICOR trial: secondary publication].

[Article in Danish]

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Copenhagen Trial Unit (CTU), Center for Klinisk Interventionsforskning, Rigshospitalet, DK-2100 København Ø. cgluud@ctu.rh.dk.

Abstract

Antibiotics may reduce cardiovascular morbidity. We randomised 4372 patients with stable coronary heart disease in the CLARICOR trial to clarithromycin 500 mg (n = 2172) or placebo (n = 2200) daily for a fortnight. After 2.6 years we found significantly increased cardiovascular mortality among the clarithromycin patients. There is a need for studies to evaluate the safety of clarithromycin. There is presently no evidence to support the preventive effect of antibiotics on patients with coronary heart disease.

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BMJ. 2006 Jan 7;332(7532):22-7.

PMID:: 17303029; [PubMed]

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