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    Vnitr Lek. 2006 Dec;52(12):1194-9.

    [ZAP-70 in B-cell chronic lymphocytic leukemia: clinical significance and methods of detection].

    [Article in Czech]
    Smolej L, Saudková L, Spacek M, Kozák T.

    Source

    Oddelení klinické hematologie II. interní kliniky Lékarské fakulty UK a FN Hradec Králové. smolej@seznam.cz

    Abstract

    B-cell chronic lymphocytic leukemia (B-CLL) represents a heterogeneous disease with highly variable prognosis. Clinical staging systems (Rai, Binet) fail to accurately predict the prognosis of individual patients, especially in early stages. Modern prognostic markers, mainly the mutational status of the variable regions of immunoglobulin heavy chains (IgVH) and genetic aberrations, allow more accurate risk stratification. Assessment of the expression of intracellular protein tyrosine kinase ZAP-70 represents not only a potential surrogate marker for the technically difficult and routinely unavailable assessment of the IgVH mutational status, but might also be an independent prognostic factor. Study of ZAP-70 function in B-cells has broadened our knowledge on the pathogenesis of B-CLL. Routine ZAP-70 assessment has been hindered so far mainly by the lack of harmonization and standardization of the available methods of detection.

    Comment in

    PMID:
    17299914
    [PubMed - indexed for MEDLINE]

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