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Nat Rev Mol Cell Biol. 2007 Mar;8(3):245-57. Epub 2007 Feb 14.

In search of partners: linking extracellular proteases to substrates.

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  • 1The UBC Centre for Blood Research, CBCRA Program in Breast Cancer Metastasis, Department of Oral Biological & Medical Sciences, University of British Columbia, 4.401 Life Sciences Center, Vancouver, British Columbia, V6T 1Z3, Canada.

Abstract

Proteases function as molecular switches in signalling circuits at the cell surface and in the extracellular milieu. In light of the many proteases that are encoded by the genome, and the even larger number of bioactive substrates, it is crucial to identify which proteases cleave a particular substrate and which substrates individual proteases cleave. Elucidating the substrate degradomes of proteases will help us to understand the function of proteases in development and disease and to validate proteases as drug targets.

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