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    Am J Hum Genet. 1992 Jan;50(1):71-5.

    The gene for human erythrocyte protein 4.2 maps to chromosome 15q15.

    Najfeld V, Ballard SG, Menninger J, Ward DC, Bouhassira EE, Schwartz RS, Nagel RL, Rybicki AC.

    Source

    Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, Mount Sinai School of Medicine, New York, NY.

    Abstract

    Protein 4.2 (P4.2), one of the major components of the red-blood-cell membrane, is located on the interior surface, where it binds with high affinity to the cytoplasmic domain of band 3. Individuals whose red blood cells are deficient in P4.2 have osmotically fragile, abnormally shaped cells and moderate hemolytic anemia. cDNA clones from both the 5' and the 3' coding regions of the P4.2 gene were used to map its chromosomal location by fluorescence in situ hybridization. The probes, individually or in combination, gave specific hybridization signals on chromosome 15. The hybridization locus was identified by combining fluorescence images of the probe signals with fluorescence banding patterns generated by Alu-PCR (R-like) probe and by DAPI staining (G-like). Our results demonstrate that the locus of the P4.2 gene is located within 15q15.

    PMID:
    1729896
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1682530
    Free PMC Article

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