Monitoring serum free light chains in patients with multiple myeloma who achieved negative immunofixation after allogeneic stem cell transplantation

Ulrike Mösbauer; Francis Ayuk; Heike Schieder; Michael Lioznov; Axel R Zander; Nicolaus Kröger

doi:10.3324/haematol.10568

Monitoring serum free light chains in patients with multiple myeloma who achieved negative immunofixation after allogeneic stem cell transplantation

Haematologica. 2007 Feb;92(2):275-6. doi: 10.3324/haematol.10568.

Authors

Ulrike Mösbauer, Francis Ayuk, Heike Schieder, Michael Lioznov, Axel R Zander, Nicolaus Kröger

PMID: 17296589
DOI: 10.3324/haematol.10568

Abstract

Monitoring of serum free immunoglobulin light chains (FLC) in 26 myeloma patients who achieved immunofixation negativity after allografting showed a decrease of FLC at a median of 128 days before immunofixation negativity. In patients who subsequently relapsed, a 25% increase of FLC was observed at a median of 98 days before immunofixation positivity.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Binding Sites
Biomarkers, Tumor / blood
Female
Follow-Up Studies
Humans
Immunoglobulin Light Chains / blood*
Male
Middle Aged
Multiple Myeloma / blood*
Multiple Myeloma / therapy*
Remission Induction
Stem Cell Transplantation / methods*
Time Factors
Treatment Outcome

Substances

Biomarkers, Tumor
Immunoglobulin Light Chains