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J Consult Clin Psychol. 2007 Feb;75(1):85-94.

Fluoxetine, smoking, and history of major depression: A randomized controlled trial.

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  • 1Psychology Department, University of Illinois at Chicago, Chicago, IL, USA. bspring@northwestern.edu

Abstract

The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.

Copyright 2007 APA, all rights reserved.

PMID:
17295567
[PubMed - indexed for MEDLINE]
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