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J Bacteriol. 2007 Apr;189(8):3306-11. Epub 2007 Feb 9.

Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation.

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  • 1Space Life Sciences Laboratory, Building M6-1025/SLSL, Kennedy Space Center, FL 32953, USA.

Abstract

The role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants (recA, splB, ykoU, ykoV, and ykoU ykoV mutants) of Bacillus subtilis. NHEJ-defective spores with mutations in ykoU, ykoV, and ykoU ykoV were significantly more sensitive to UV, ionizing radiation, and ultrahigh vacuum than wild-type spores, indicating that NHEJ provides an important pathway during spore germination for repair of DNA double-strand breaks.

PMID:
17293412
[PubMed - indexed for MEDLINE]
PMCID:
PMC1855867
Free PMC Article

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