Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 2007 Apr;119(4):960-4. Epub 2007 Feb 9.

Tolerability to nabumetone and meloxicam in patients with nonsteroidal anti-inflammatory drug intolerance.

Author information

  • 1Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain. aprieto.hgugm@salud.madrid.org

Abstract

BACKGROUND:

Because nonsteroidal anti-inflammatory drug (NSAID) intolerance depends on COX-1 inhibition, preferential or selective COX-2 inhibitors have been thought to be well tolerated by these patients.

OBJECTIVE:

The aim of this study is to evaluate tolerability to nabumetone and meloxicam in patients with NSAID intolerance.

METHODS:

Seventy patients intolerant to NSAIDs were selected. Thirty subjects were patients with asthma with respiratory (rhinitis-asthma) intolerance to NSAIDs (group A); 40 patients (group B) had cutaneous-mucous (urticaria-angioedema) NSAID intolerance. Diagnosis was based on clinical histories in all patients, and it was confirmed by positive single-blind placebo-controlled oral challenge test in 36 patients. After written informed consent, a single-blind placebo-controlled oral challenge test with nabumetone in all patients (2 g except for 11 patients who reached 1 g) and meloxicam (15 mg) in 51 patients was performed.

RESULTS:

Of the total selected, 94.3% tolerated 1 g nabumetone. In those who reached the 2-g dose, the tolerability was 83.6%. With respect to meloxicam, 96.1% of patients, tolerated 15 mg. No significant difference in nabumetone and meloxicam tolerability was observed between groups A and B.

CONCLUSION:

The results of this study confirm a high percentage of tolerability to the maximum therapeutic dosage of nabumetone and meloxicam in patients with NSAID intolerance, both in those with cutaneous/mucous manifestations and in those with respiratory disease.

CLINICAL IMPLICATIONS:

Nabumetone and meloxicam are safe alternatives in NSAID-intolerant patients.

PMID:
17292954
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk