Display Settings:

Format

Send to:

Choose Destination

    Cancer Cell. 2007 Feb;11(2):99-101.

    Inflammatory tales of liver cancer.

    Hoffmann A, Xia Y, Verma IM.

    Signaling Systems Laboratory, University of California, San Diego, La Jolla, CA 92093, USA.

    Comment on:

    Cell culture studies have established NF-kappaB's critical role in cancer cell survival and proliferation and led to the clinical use of NF-kappaB inhibitors. However, a paper in this issue of Cancer Cell reveals an anticancer function for NF-kappaB in a mouse model where NF-kappaB activity is lost specifically in hepatocytes. These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer.

    PMID: 17292819 [PubMed - indexed for MEDLINE]

    Supplemental Content

    Click here to read