Comment on:

Cancer Cell. 2007 Feb;11(2):119-32.

Inflammatory tales of liver cancer.

Signaling Systems Laboratory, University of California, San Diego, La Jolla, CA 92093, USA.

Cell culture studies have established NF-kappaB's critical role in cancer cell survival and proliferation and led to the clinical use of NF-kappaB inhibitors. However, a paper in this issue of Cancer Cell reveals an anticancer function for NF-kappaB in a mouse model where NF-kappaB activity is lost specifically in hepatocytes. These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer.

PMID: 17292819 [PubMed - indexed for MEDLINE]