Late-onset self-healing reticulohistiocytosis: pediatric case of Hashimoto-Pritzker type Langerhans cell histiocytosis

J Dermatol. 2007 Mar;34(3):205-9. doi: 10.1111/j.1346-8138.2007.00251.x.

Abstract

An 8-year-old otherwise healthy girl presented with a 3-month history of multiple asymptomatic, reddish-brown papules over the face and upper limbs. Histopathological and immunohistochemical examinations demonstrated an infiltrate of mononuclear cells containing abundant histiocytic cells in the dermis, and microabscess-like accumulation of the histiocytic cells in the epidermis. The histiocytic cells were positive for antibodies against S-100 protein and CD1a, but negative for anti-CD68. Lag and anti-langerin monoclonal antibodies reacted more weakly with these histiocytic cells than with Langerhans cells in the surrounding epidermis. The skin lesions spontaneously regressed within the following 3 months, and neither systemic involvement nor local recurrence was observed during the next 10 months. This case should be categorized as congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker), although the onset was not early in life.

Publication types

  • Case Reports

MeSH terms

  • Age of Onset
  • Arm / pathology
  • Child
  • Face / pathology
  • Female
  • Histiocytes / immunology
  • Histiocytes / pathology
  • Histiocytosis, Langerhans-Cell / pathology*
  • Humans
  • Langerhans Cells / immunology
  • Langerhans Cells / pathology
  • Skin / pathology*