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Schizophr Bull. 2007 Nov;33(6):1319-23. Epub 2007 Feb 7.

Failure to find P50 suppression deficits in young first-episode patients with schizophrenia and clinically unaffected siblings.

Author information

  • 1Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Tafelbergweg 25, 1105 BC, Amsterdam, The Netherlands. o.dewilde@amc.uva.nl

Abstract

OBJECTIVE:

To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings.

METHODS:

An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model.

RESULTS:

P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls.

CONCLUSIONS:

P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.

PMID:
17289652
[PubMed - indexed for MEDLINE]
PMCID:
PMC2779877
Free PMC Article
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