Abstract
The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), alpha-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH. The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide. Maximal activity is a characteristic of silistrong.
MeSH terms
-
Animals
-
Antioxidants / metabolism
-
Antioxidants / pharmacology
-
Central Nervous System Depressants / metabolism
-
Central Nervous System Depressants / pharmacology
-
Cytoplasm / enzymology*
-
Enzyme Activation / drug effects
-
Erythrocytes / enzymology
-
Ethanol / metabolism*
-
Ethanol / pharmacology
-
Hydrogen Peroxide / metabolism*
-
Hydrogen Peroxide / pharmacology
-
Oxidants / metabolism
-
Oxidants / pharmacology
-
Oxidoreductases / metabolism*
-
Rabbits
-
Silymarin / metabolism*
-
Silymarin / pharmacology
Substances
-
Antioxidants
-
Central Nervous System Depressants
-
Oxidants
-
Silymarin
-
Ethanol
-
Hydrogen Peroxide
-
Oxidoreductases