Synthesis of S-dialkylarsino-3-mercapto-1,2-propanediols and evaluation of their anticancer activity

Mingzhang Gao; Songde Tan; Yiwen Chen; Ralph A Zingaro

doi:10.1016/j.bmc.2007.01.038

Synthesis of S-dialkylarsino-3-mercapto-1,2-propanediols and evaluation of their anticancer activity

Bioorg Med Chem. 2007 Apr 1;15(7):2660-6. doi: 10.1016/j.bmc.2007.01.038. Epub 2007 Jan 24.

Authors

Mingzhang Gao¹, Songde Tan, Yiwen Chen, Ralph A Zingaro

Affiliation

¹ Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.

PMID: 17287125
DOI: 10.1016/j.bmc.2007.01.038

Abstract

Some new S-dialkylarsenic compounds, S-dialkylarsino-3-mercapto-1,2-propanediol (3a-3d) and their derivatives (4a,4b), have been synthesized. They were screened at the National Cancer Institute (NCI) for their anticancer activity against a panel of about 60 human tumor cell lines. Most of them display anticancer activity having GI(50) and LC(50) values at low concentrations and are sensitive to leukemia, renal cancer and prostate cancer cell lines and in which the compound 3c is the most active.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Glycerol / analogs & derivatives*
Glycerol / chemical synthesis*
Glycerol / pharmacology*
Humans
Indicators and Reagents
Lethal Dose 50
Magnetic Resonance Spectroscopy
Mass Spectrometry
Structure-Activity Relationship
Sulfhydryl Compounds / chemical synthesis*
Sulfhydryl Compounds / pharmacology*

Substances

Antineoplastic Agents
Indicators and Reagents
Sulfhydryl Compounds
Glycerol