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Pharmacoepidemiol Drug Saf. 2007 Jul;16(7):746-52.

Reasons for antidepressant prescriptions in Canada.

Author information

  • 1University of Calgary, Calgary, Canada. patten@ucalgary.ca

Abstract

PURPOSE:

To describe reasons reported by physicians making recommendations for treatment with antidepressant medications.

METHODS:

Data collected by IMS Health Canada in a database called the Canadian Disease and Therapeutic Index (CDTI) were used in this analysis. CDTI data are collected from a representative sample of office-based physicians who complete diaries in their practices during selected sampling periods. A drug recommendation is recorded each time a treatment is recommended. The data are weighted to produce national estimates of the frequency of such recommendations.

RESULTS:

The frequency of recommendations for antidepressant treatment increased between 2000 and 2004. However, there was a slight decrease in 2005. Two types of antidepressant medications, tricyclic antidepressants (TCAs) and trazodone showed distinct patterns of use. TCAs were more commonly used for non-psychiatric indications than for psychiatric indications, especially for sleep- and pain-related reasons. Trazodone was frequently recommended for sleep problems. The proportion of recommendations for depressive disorders for antidepressants as a group remained stable over the 5-year study period.

CONCLUSIONS:

About one-third of antidepressant recommendations are for reasons other than depression. It can no longer be assumed that the frequency of antidepressant use is a measure of the frequency of pharmacological depression treatment. However, prescription data may be useful for tracking trends.

PMID:
17286318
[PubMed - indexed for MEDLINE]
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