Heart Vessels. 2007 Jan;22(1):64-6. Epub 2007 Jan 26.

Warfarin-induced skin necrosis after open heart surgery due to protein S and C deficiency.

Oz BS, Asgun F, Oz K, Kuralay E, Tatar H.

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Department of Cardiovascular Surgery, Gulhane Military Medical Academy, Etlik, Ankara, 06018, Turkey. bsavoz@yahoo.com

Abstract

Warfarin-induced skin necrosis is the rare but potentially devastating complication of anticoagulant therapy and commonly occurs in previously undetected C- and S-protein deficient patients. Because routine preoperative examination does not include protein C and S level measurement, detection of these patients preoperatively is generally not possible, which increases the risk of occurrence of this important complication. In this report we present and discuss such a patient, who died from warfarin-induced skin necrosis after coronary artery bypass surgery.

PMID:: 17285450; [PubMed - indexed for MEDLINE]

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