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Br J Cancer. 2007 Feb 12;96(3):510-3.

Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study.

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  • 1Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.


Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.

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