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Int J Gynaecol Obstet. 2007 Mar;96(3):212-8. Epub 2007 Feb 5.

Alternatives to mifepristone for early medical abortion.

Author information

  • 1Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA. Nilda.Moreno@bmc.org

Abstract

OBJECTIVE:

To review published reports of first-trimester medical abortion regimens that do not include mifepristone.

METHODS:

Reports listed in Pubmed and Medline on prospective and controlled trials of the efficacy of misoprostol, alone or associated with methotrexate, for first-trimester abortion were analyzed if they included more than 100 participants and were published since 1990.

RESULTS:

The efficacy of regimens using misoprostol alone ranged from 84% to 96%, and when misoprostol was used with methotrexate the efficacy ranged from 70% to 97%. Efficacy rates were influenced by follow-up interval. Treatment for infection, bleeding, and incomplete abortion were infrequent with both methods (0.3%-5%).

CONCLUSION:

Alone or in combination with methotrexate, misoprostol is an efficacious alternative to mifepristone for the medical termination of pregnancy.

PMID:
17280669
[PubMed - indexed for MEDLINE]
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