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    Anaesthesist. 2007 May;56(5):449-53.

    [Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion]

    [Article in German]

    Zimmer C, Piepenbrink K, Riest G, Peters J.

    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Deutschland. christian.zimmer@uk-essen.de

    Accidental intravascular administration of bupivacaine can cause severe neurotoxic and cardiotoxic effects. We report a case of suspected bupivacaine intoxication due to intravascular injection via an epidural catheter and treatment with lidocaine, propofol, and a 20% lipid emulsion resulting in fast resolution of cardiotoxic and neurotoxic effects. Possible mechanisms of action of the medications used are discussed.

    PMID: 17277955 [PubMed - indexed for MEDLINE]

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    • Fat Emulsions for Injection (Intralipid®, Liposyn®)

      Your doctor has ordered fat emulsion to be used as a source of calories and fatty acids to maintain or increase your weight. The medication will be diluted in a total parenteral nutrition (TPN) solution or in a separate ...