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Cell Metab. 2007 Feb;5(2):85-7.

The metabolic sensor GCN2 branches out.

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  • 1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. towle@mail.ahc.umn.edu

Abstract

GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.

PMID:
17276350
[PubMed - indexed for MEDLINE]
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