Putting transcription repression and protein destruction in pRb's pocket

Emmy W Verschuren; Peter K Jackson

doi:10.1016/j.devcel.2007.01.015

Putting transcription repression and protein destruction in pRb's pocket

Dev Cell. 2007 Feb;12(2):169-70. doi: 10.1016/j.devcel.2007.01.015.

Authors

Emmy W Verschuren¹, Peter K Jackson

Affiliation

¹ Genentech, Inc., South San Francisco, CA 94080, USA.

PMID: 17276331
DOI: 10.1016/j.devcel.2007.01.015

Abstract

The tumor suppressor function of the retinoblastoma protein (pRb) is historically attributed to inhibition of E2F gene transcription. In a recent issue of Nature Cell Biology, Binné and colleagues show that pRB is physically linked to the active anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase, suggesting that pRB-mediated tumor suppression may also function by directing the local degradation of E2F targets, including Skp2 (Binné et al., 2006).

MeSH terms

Anaphase-Promoting Complex-Cyclosome
Animals
E2F Transcription Factors / genetics
Protein Processing, Post-Translational*
Repressor Proteins / metabolism*
Retinoblastoma Protein / metabolism*
S-Phase Kinase-Associated Proteins / metabolism
Transcription, Genetic*
Ubiquitin-Protein Ligase Complexes / metabolism

Substances

E2F Transcription Factors
Repressor Proteins
Retinoblastoma Protein
S-Phase Kinase-Associated Proteins
Ubiquitin-Protein Ligase Complexes
Anaphase-Promoting Complex-Cyclosome