Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Result Filters

Virology. 2007 Jun 5;362(2):314-9. Epub 2007 Feb 2.

Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.

Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.

Source

Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 2502, 40 Convent Drive, MSC 3017, Bethesda, MD 20892-3017, USA.

Abstract

CD8+ cytotoxic T lymphocytes are key effectors of adaptive immunity for the control of virus infections. Epitope-specific responses are hierarchical and the rules for dominance are not well defined. Here we show that the H2-Kd-restricted RSV M2(82-90) (KdM2(82-90)) epitope dominates the H2-Db-restricted RSV M187-195 (DbM187-195) epitope and influences epitope-specific effector function in the acute and memory phases of the immune response to primary RSV infection in H-2b/d hybrid mice. The hybrid mouse model provides a system to define rules of epitope hierarchy and better understand how antigen presentation and epitope competition affect the phenotype of effector and memory T cells.

PMID:: 17275872; [PubMed - indexed for MEDLINE]
PMCID:: PMC1950131

Free PMC Article

Images from this publication.See all images (4) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Respiratory Syncytial Virus Infections - MedlinePlus Health Information

Molecular Biology Databases

Related Immune Epitope Information - Immune Epitope Database and Analysis Resource

Supplemental Content

Icon for Elsevier Science

Icon for PubMed Central

Save items

loading

Related citations in PubMed

Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope. [J Immunol. 2010]
Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope.
Ruckwardt TJ, Luongo C, Malloy AM, Liu J, Chen M, Collins PL, Graham BS. J Immunol. 2010 Oct 15; 185(8):4673-80. Epub 2010 Sep 10.
Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model. [J Virol. 2009]
Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model.
Liu J, Ruckwardt TJ, Chen M, Johnson TR, Graham BS. J Virol. 2009 May; 83(10):4934-41. Epub 2009 Mar 4.
Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. [J Virol. 2009]
Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities.
Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS. J Virol. 2009 Apr; 83(7):3019-28. Epub 2009 Jan 19.
Review Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease. [Immunol Res. 2007]
Review Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease.
Castilow EM, Olson MR, Varga SM. Immunol Res. 2007; 39(1-3):225-39.
Review Respiratory syncytial virus and T cells: interplay between the virus and the host adaptive immune system. [Proc Am Thorac Soc. 2005]
Review Respiratory syncytial virus and T cells: interplay between the virus and the host adaptive immune system.
Braciale TJ. Proc Am Thorac Soc. 2005; 2(2):141-6.

See reviews... See all...

Cited by 9 PubMed Central articles

Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice. [PLoS Pathog. 2011]
Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice.
Ruckwardt TJ, Malloy AM, Gostick E, Price DA, Dash P, McClaren JL, Thomas PG, Graham BS. PLoS Pathog. 2011 Dec; 7(12):e1002377. Epub 2011 Dec 1.
Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses. [PLoS One. 2011]
Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses.
Molinari P, Crespo MI, Gravisaco MJ, Taboga O, Morón G. PLoS One. 2011; 6(8):e24108. Epub 2011 Aug 30.
Major histocompatibility complex-dependent cytotoxic T lymphocyte repertoire and functional avidity contribute to strain-specific disease susceptibility after murine respiratory syncytial virus infection. [J Virol. 2011]
Major histocompatibility complex-dependent cytotoxic T lymphocyte repertoire and functional avidity contribute to strain-specific disease susceptibility after murine respiratory syncytial virus infection.
Jessen B, Faller S, Krempl CD, Ehl S. J Virol. 2011 Oct; 85(19):10135-43. Epub 2011 Jul 27.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mou...
Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Virology. 2007 Jun 5 ;362(2):314-9. Epub 2007 Feb 2 .

PubMed
Sonographic diagnosis of the large for gestational age fetus at term: does it ma...
Sonographic diagnosis of the large for gestational age fetus at term: does it make a difference?
Obstet Gynecol. 1992 Jan ;79(1):55-8.

PubMed
Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?
Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?
Toxicol Appl Pharmacol. 2007 Apr 1 ;220(1):92-107. Epub 2006 Dec 22 .

PubMed
Automated, on-line membrane extraction.
Automated, on-line membrane extraction.
J Chromatogr A. 2007 Jun 8 ;1152(1-2):199-214. Epub 2006 Dec 20 .

PubMed
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Biochem Biophys Res Commun. 2007 Mar 23 ;354(4):1021-7. Epub 2007 Jan 25 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk