Biochem Biophys Res Commun. 2007 Mar 23;354(4):1021-7. Epub 2007 Jan 25.

PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.

Hondares E, Pineda-Torra I, Iglesias R, Staels B, Villarroya F, Giralt M.

Source

Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain.

Abstract

PGC-1alpha induces mitochondrial biogenesis in muscle and its activity has been related to insulin sensitization. Here, we report that fibrates induce PGC-1alpha gene expression in muscle both in vivo and in vitro. However, only activation via PPARdelta but not PPARalpha underlies this effect. PPARdelta induces PGC-1alpha gene transcription through a PPAR-response element in the PGC-1alpha promoter. Moreover, PGC-1alpha coactivates the PPARdelta-responsiveness of its own gene. A further positive autoregulatory loop of control relies on the induction of PPARdelta expression by PGC-1alpha. These data point to a distinct value of PPARdelta rather than PPARalpha agonists in the improvement of oxidative metabolism in muscle.

PMID:: 17275789; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. [J Biol Chem. 2009]
PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.
Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z. J Biol Chem. 2009 Jul 10; 284(28):18624-33. Epub 2009 May 12.
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. [Mol Cell Biol. 2004]
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.
Huss JM, Torra IP, Staels B, Giguère V, Kelly DP. Mol Cell Biol. 2004 Oct; 24(20):9079-91.
Human skeletal muscle fibre type variations correlate with PPAR alpha, PPAR delta and PGC-1 alpha mRNA. [Acta Physiol (Oxf). 2006]
Human skeletal muscle fibre type variations correlate with PPAR alpha, PPAR delta and PGC-1 alpha mRNA.
Krämer DK, Ahlsén M, Norrbom J, Jansson E, Hjeltnes N, Gustafsson T, Krook A. Acta Physiol (Oxf). 2006 Nov-Dec; 188(3-4):207-16.
Review Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta. [Curr Diabetes Rev. 2005]
Review Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta.
Evans JL, Lin JJ, Goldfine ID. Curr Diabetes Rev. 2005 Aug; 1(3):299-307.
Review PGC-1alpha and exercise: important partners in combating insulin resistance. [Curr Diabetes Rev. 2005]
Review PGC-1alpha and exercise: important partners in combating insulin resistance.
Russell AP. Curr Diabetes Rev. 2005 May; 1(2):175-81.

See reviews... See all...

Cited by 11 PubMed Central articles

A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations. [J Cell Mol Med. 2011]
A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations.
Wenz T, Wang X, Marini M, Moraes CT. J Cell Mol Med. 2011 Nov; 15(11):2317-25.
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart. [Circ Res. 2010]
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.
Wang P, Liu J, Li Y, Wu S, Luo J, Yang H, Subbiah R, Chatham J, Zhelyabovska O, Yang Q. Circ Res. 2010 Mar 19; 106(5):911-9. Epub 2010 Jan 14.
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. [J Biol Chem. 2009]
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.
Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F. J Biol Chem. 2009 Aug 14; 284(33):21872-80. Epub 2009 Jun 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Biochem Biophys Res Commun. 2007 Mar 23 ;354(4):1021-7. Epub 2007 Jan 25 .

PubMed
Neonatal subependymal giant cell astrocytoma: new case and review of literature.
Neonatal subependymal giant cell astrocytoma: new case and review of literature.
Pediatr Neurol. 2007 Feb ;36(2):128-31.

PubMed
Return to athletic activity after total hip arthroplasty. Consensus guidelines b...
Return to athletic activity after total hip arthroplasty. Consensus guidelines based on a survey of the Hip Society and American Association of Hip and Knee Surgeons.
J Arthroplasty. 2007 Feb ;22(2):171-5.

PubMed
Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry ...
Exploratory voxel-based analysis of diffusion indices and hemispheric asymmetry in normal aging.
Magn Reson Imaging. 2007 Feb ;25(2):154-67. Epub 2006 Dec 6 .

PubMed
Ethnic differences regarding tactile and pain thresholds in the trigeminal regio...
Ethnic differences regarding tactile and pain thresholds in the trigeminal region.
J Pain. 2007 Apr ;8(4):363-9. Epub 2007 Feb 1 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information