J Neuroimmunol. 2007 Mar;184(1-2):156-63. Epub 2007 Feb 1.

Trypanosoma cruzi-triggered meningoencephalitis is a CCR1/CCR5-independent inflammatory process.

Silva AA, Roffê E, Santiago H, Marino AP, Kroll-Palhares K, Teixeira MM, Gazzinelli RT, Lannes-Vieira J.

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Laboratory of Autoimmunity and Immunoregulation, Institute Oswaldo Cruz, Fiocruz, Av. Brasil 4365, Rio de Janeiro, 21045900, Brazil.

Abstract

Encephalitis rarely occurs during acute Trypanosoma cruzi infection. However, the central nervous system (CNS) is the major site of infection reactivation in immunocompromised patients. We show that the acute T. cruzi-triggered CD8-enriched meningoencephalitis paralleled the in situ expression of CCL3/MIP-1alpha and CCL5/RANTES mRNA. The frequency of CCR5-bearing cells was increased among peripheral blood mononuclear cells (PBMC) of infected mice. Further, CCL5/RANTES-driven in vitro PBMC migration was partially abrogated by the CCR1/CCR5 antagonist Met-RANTES. However, Met-RANTES treatment of infected mice altered neither parasitism nor intensity and nature of the CNS inflammation, indicating that T. cruzi-elicited meningoencephalitis is a CCR1/CCR5 independent process.

PMID:: 17275101; [PubMed - indexed for MEDLINE]

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