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Genome Biol. 2007;8(1):201.

Analysis of genetic systems using experimental evolution and whole-genome sequencing.

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  • 1Department of Systems Biology, Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA.

Abstract

The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.

PMID:
17274841
[PubMed - indexed for MEDLINE]
PMCID:
PMC1839123
Free PMC Article
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