J Neurochem. 1992 Jan;58(1):116-20.

Determination of acidic metabolites of biogenic amines in human aqueous humour by gas chromatography--negative ion chemical ionisation mass spectrometry.

Watson DG, McGhee CN, Midgley JM, Zhou P, Doig WM.

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Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, Scotland, U.K.

Abstract

The concentrations of acidic metabolites derived from the biogenic amines o-, m-, and p-tyramines (o-, m-, and p-hydroxyphenylacetic acids), p-octopamine/p-synephrine (p-hydroxymandelic acid), and dopamine (homovanillic acid and 3,4-dihydroxyphenylacetic acid) were measured in human aqueous humour obtained from patients undergoing elective surgery for cataract removal or for trabeculectomy as a treatment for chronic open-angle glaucoma. There were no clear differences in the pattern of metabolism of neurotransmitters between the two groups. An unexpected finding was that the o-tyramine metabolite, o-hydroxyphenylacetic acid, was present in aqueous humour.

PMID:: 1727423; [PubMed - indexed for MEDLINE]

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