Circ Res. 2007 Feb 2;100(2):174-90.

Phenotypic heterogeneity of the endothelium: II. Representative vascular beds.

Source

Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA. waird@bidmc.harvard.edu

Abstract

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function. This is the second of a 2-part review on the phenotypic heterogeneity of blood vessel endothelial cells. The first part discusses the scope, the underlying mechanisms, and the diagnostic and therapeutic implications of phenotypic heterogeneity. Here, these principles are applied to an understanding of organ-specific phenotypes in representative vascular beds including arteries and veins, heart, lung, liver, and kidney. The goal is to underscore the importance of site-specific properties of the endothelium in mediating homeostasis and focal vascular pathology, while at the same time emphasizing the value of approaching the endothelium as an integrated system.

PMID:: 17272819; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. [Circ Res. 2007]
Review Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.
Aird WC. Circ Res. 2007 Feb 2; 100(2):158-73.
Review Normal endothelium. [Handb Exp Pharmacol. 2006]
Review Normal endothelium.
Pries AR, Kuebler WM. Handb Exp Pharmacol. 2006; (176 Pt 1):1-40.
Review Endothelium in health and disease. [Pharmacol Rep. 2008]
Review Endothelium in health and disease.
Aird WC. Pharmacol Rep. 2008 Jan-Feb; 60(1):139-43.
Review Endothelium and allotransplantation. [Transplantation. 2006]
Review Endothelium and allotransplantation.
Aird WC. Transplantation. 2006 Jul 15; 82(1 Suppl):S6-8.
Review Morphological heterogeneity of endothelium. [Semin Thromb Hemost. 2010]
Review Morphological heterogeneity of endothelium.
Tse D, Stan RV. Semin Thromb Hemost. 2010 Apr; 36(3):236-45. Epub 2010 May 20.

See reviews... See all...

Cited by 64 PubMed Central articles

Microvascular guidance: a challenge to support the development of vascularised tissue engineering construct. [ScientificWorldJournal. 2012]
Microvascular guidance: a challenge to support the development of vascularised tissue engineering construct.
Sukmana I. ScientificWorldJournal. 2012; 2012:201352. Epub 2012 Apr 24.
Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. [PLoS One. 2012]
Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids.
Géraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, et al. PLoS One. 2012; 7(4):e34206. Epub 2012 Apr 3.
O2-filled swimbladder employs monocarboxylate transporters for the generation of O2 by lactate-induced root effect hemoglobin. [PLoS One. 2012]
O2-filled swimbladder employs monocarboxylate transporters for the generation of O2 by lactate-induced root effect hemoglobin.
Umezawa T, Kato A, Ogoshi M, Ookata K, Munakata K, Yamamoto Y, Islam Z, Doi H, Romero MF, Hirose S. PLoS One. 2012; 7(4):e34579. Epub 2012 Apr 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Phenotypic heterogeneity of the endothelium: II. Representative vascular beds.
Phenotypic heterogeneity of the endothelium: II. Representative vascular beds.
Circ Res. 2007 Feb 2 ;100(2):174-90.

PubMed
Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled no...
Diagnosis of bone, joint, and joint prosthesis infections with In-111-labeled nonspecific human immunoglobulin G scintigraphy.
Radiology. 1992 Jan ;182(1):195-9.

PubMed
Physical activity and type 2 diabetes: exploring the role of gender and income.
Physical activity and type 2 diabetes: exploring the role of gender and income.
Diabetes Educ. 2007 Jan-Feb ;33(1):128-43.

PubMed
Strong association of the rest-activity rhythm with well-being in demented elder...
Strong association of the rest-activity rhythm with well-being in demented elderly women.
Am J Geriatr Psychiatry. 2007 Feb ;15(2):92-100.

PubMed
The DEAD-box RNA helicase Dbp5 functions in translation termination.
The DEAD-box RNA helicase Dbp5 functions in translation termination.
Science. 2007 Feb 2 ;315(5812):646-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: